I done both! The SNES game is way better designed but the Genesis one I liked the world a lot more.
The Genesis version was pretty clearly rushed for development because the actual plot you have to go through is pretty thin all in all. Easiest strategy is to start as a Samurai, make enough money to hire the good decker (Rianna Heartbane, I think)-- and to get out of Redmond Barrens, obv-- hack random systems until you can buy a good deck, hire the decker permanently, hack better systems, make more money, get your Reputation high enough to take Matrix runs from Caleb Brightmore for more cash/karma. Rinse/repeat until you want to get to the plot stuff.
There’s also a title screen cheat:
Enter ABBACAB on the start screen before pressing start. This will open a secret menu option that’s blank on the menu screen during the game. You can use this to get one crazy boost for the game-- 250,000 nuyen, +10 Karma, “Test Deck”, and more; but you can save the game, reload, and do it again. If you really want to go this route, get the money and the deck, get Karma until you have good stats, then use “Walk Fast” for the rest of the game.