SARS-CoV-2: Electric Superflu

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I really wonder where this site is getting their data. I picked two of the people at the top of the list of contributors and emailed them about it.

If you didn’t pay rent or have health insurance, which alone individually are more than that amount for that time period and were frugal like me you could do it.

Likely someone he currently thinks is cool used it in his presence in the last 48 hours.

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I have to go do laundry at the laundromat. Seems like one of the worst places to go.

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So we are supposed to believe Florida had 0 corona deaths today. Jlawok.gif

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Now there is an actual expert instead of what passes for a half-ass one ITT.

One thing that sucks about the seasonal flu is the variability in its antigen properties. Vaccines are based on the most likely antigens present at the end of the previous seasonal flu. Some years it’s quite effective some years it’s not as the dominant variant didn’t make itself known the previous cycle. Once in awhile it throws out something different enough that neither the vaccine nor our previous encounters with the flu provide much protection (1918, H1N1 cases in point).

I hope as he notes that CV continues to not mutate it’s antigen profile. No clue how common or not that is in coronavirus. The fact that SARS hasn’t been a common thing gives me hope that it is uncommon to change antigens.

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the lord works in mysterious ways

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Prop him up beside the jukebox

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haha holy fucking shit this is a real story about my friend and old college roommate who is literally the most stoked surfer i have ever met in my entire life. he’d surf alone out front of our house in 1 ft blown out shit and come in and talk about how sick it was a how much fun he had like some kind of lunatic. he lives in an oceanfront apartment in san francisco and when i was there last fall visiting another friend i surfed with him and his girlfriend twice lol

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Stupid question time again…

Is the antigen the “hook protein” that you hear talked about? Isn’t that hook thing the only way it manages to invade a cell? It would seem unlikely for that to mutate since it would probably mutate itself out of existence?

I am unsure. I can see two meanings.

Hook could be something on your cells “Receptor” that the virus grabs onto to attach and then get inside the cell

Or

Hook could mean as you describe.

All these things are proteins so it may be likely they are one and the same, though I am unsure of that is true all the time, true mostly, or true some of the time.

When he says spike I’m pretty sure he means the apparatus on the virus protein envelope that grabs onto the host cell and helps inject the virus inside.

You can do your laundry at home. I was stranded at home for a month after Hurricane Irma. All you need is a plunger (buy a new one and use it specifically for this). Put some clothes in the tub, fill it with hot water until the tub is half full and add detergent. Then use the plunger to aerate the water as much as you can. Just stir it for like 5 minutes. You’ll be surprised at how dirty the water gets LOL. Then rinse the clothes and squeeze as much water as you can before hanging the clothes up. If you do a little each day, entire thing takes like 20 minutes. And your clothes will be dry by the next day. Hang them on the back of chairs or whatever.

I mean it’s gonna be a pain in the ass but it’s better than going to a laudromat. And don’t wait til all your clothes are dirty because it will take hours to wash and clean everything. The hardest part is squeezing the water out after cleaning. After Irma, I did my laundry every other day.

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This is good advice but mistakes have been made wrt this.

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Some small good news. Th exponent seems to be going down, 0.25ish from close to 0.3 a week ago.

2.75 day doubling death rate vs 2.4 last week (Sunday to Sunday).

Should push 1,000/day out to 4/1 or 4/2 if this holds.

New York still dominating the data and is closer to 0.28. WA and CA bring down the national number. Unless NY slows down it will go back up. LA and MI on the move in the wrong direction.

I see 900+ cases and 4 deaths.

@suzzer99 , you might like this podcast episode, they talk about the seasonal nature of viruses and how they’re affected by temperature and humidity.

https://www.sciencemag.org/podcast/why-some-diseases-come-and-go-seasons-and-how-develop-smarter-safer-chemicals

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Another CPAP development


Unlike a simple face mask linked to an oxygen supply, CPAP delivers air and oxygen under pressure, so there needs to be a mask creating a tight seal on the patient’s face, over their mouth and nose or a transparent hood over their head.

so the guy @Jalfrezi posted in the goofs/memrs thread


maybe needs to be taken more seriously.

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Technically, an “antigen” is any substance that generates an immune response, whether that’s a viral protein, a bacterial carbohydrate cell wall, or a grain of pollen.

For coronaviruses of all types, they have “spike” proteins (technically glycoproteins, as they have sugar groups latched onto them as well) sticking out all over their surfaces. These are the obvious antigens for your immune cells to recognize. It would seem that they could also be amenable to mutation and immune escape, but since they are involved in host cell invasion, there is also some competing pressure to keep them the same. With most proteins, there are certain amino acids in the chain that can be replaced with just about anything, or at least one of a few similar amino acids, and there are some that are highly if not absolutely conserved and that can’t be changed without killing off the whole functionality of the protein.

In the course of the pandemic, there will be mutations, lots of them, and some of them will be terminal, but there are so many viruses that a few lost to bad mutations doesn’t make a difference, while a few successful mutations can change the whole ballgame.

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Wearing minimal clothes and hand washing seems like an option. Sheets are the biggest pain.