2022 LC Thread—New Year, New Thread

[Mr_Unstoppable]

@ChrisV

I sent a friend home using my account one time when he was super drunk, so that might be the 1 star.

I did this to a friend one time

Mine:

[Tilted]

Losers. I get pretty chatty after a few drinks so I assume my 1 and 2 stars are because I pissed someone off for asking personal questions.

[anon10387340]

How long did it take to get your data? All I got was an email saying that they received my request.

[Tilted]

You can see it in the app. Go to settings: privacy: privacy center: “Would you like to see a summary of how you use Uber?”: view my ratings.

[NotBruceZ]

I’ve never used Uber.

[Tilted]

Wait… really? Lyft or you don’t use rideshare at all?

[anon10387340]

Not as many rides as I thought. But now I realize that we all took turns using our accounts so it makes sense. I’m going with a misclick on my single 1 star.

[Tilted]

Pack it in folks. Jbro wins. Not a single 2 or 3 is crazy.

[Mr_Unstoppable]

4.90853659
4.90163934

all i need is 5 perfect rides to pass you!

[NotBruceZ]

I prefer not to use rideshare. I’ve used Lyft twice when I had no other option.

[NotBruceZ]

I have also never used PayPal.

[sriracha]

My 5 1-stars situation has me shook. Am I an awful person?

I hardly ever talk! Maybe I’m getting 1-starred by the OMCs that drive for the social interaction?

I’ve never:

• Booted in a car
• Gotten into an altercation with a driver
• Had any kind of conversation (with a passenger or the driver) that could be construed as offensive
• Spilled anything or eaten anything smelly while in a ride

I dunno, I’m at a loss.

[anon10387340]

They don’t see tips until after they rate you, correct? Otherwise that could explain it. (Not meaning to imply anybody is cheap. But I tip Uber drivers heavily. Usually 100 percent on the mostly short rides I take.)

[CaffeineNeeded]

When I drove for Uber I gave bad reviews for not showing up on time for your damn ride a lot. Or not being where you said you would.

[zikzak]

I’ve never used any rideshare at all. I’ve taken maybe 10 taxis in my life, bump that up to 25 if you count tuktuks. If I’m not in my own vehicle it’s public transit or I walk.

[anon10387340]

You have taken a lot of rides. You’re getting 1 star only once in each ~ 100 trips. I wouldn’t worry about it.

[Devil]

Same except I don’t know what a tuktuk is and most of the taxis were in Mexico at a time when they were very, very cheap.

[otatop]

Two decades of Alzheimer's research may be based on deliberate fraud that has...

Last month, drug company Genentech reported on the first clinical trials of the drug crenezumab, a drug targeting amyloid proteins that form sticky plaques in the brains of Alzheimer’s disease patients. The drug had been particularly effective in animal models, and the trial results were eagerly awaited as one of the most promising treatments in years. It did not work. “Crenezumab did not slow or prevent cognitive decline” in people with a predisposition toward Alzheimer’s.

Last year, the Food and Drug Administration (FDA) narrowly approved the use of Aduhelm, a new drug from Biogen that the company has priced so highly that it’s expected to drive up the price of Medicare for everyone in America, even those who never need this drug. Aduhelm was the first drug to be approved that fights the accumulation of those “amyloid plaques” in the brain. What makes the approval of the $56,000-a-dose drug so controversial is that while it does decrease plaques, it doesn’t actually slow Alzheimer’s. In fact, clinical trials were suspended in 2019 after the treatment showed “no clinical benefits.” (Which did not keep Biogen from seeking the drug’s approval or pricing it astronomically.)

Over the last two decades, Alzheimer’s drugs have been notable mostly for having a 99% failure rate in human trials. It’s not unusual for drugs that are effective in vitro and in animal models to turn out to be less than successful when used in humans, but Alzheimer’s has a record that makes the batting average in other areas look like Hall of Fame material.

And now we have a good idea of why. Because it looks like the original paper that established the amyloid plaque model as the foundation of Alzheimer’s research over the last 16 years might not just be wrong, but a deliberate fraud.

Looks like another instance of years of medical research being founded on a bullshit paper.

[zikzak]

One of these:

Auto rickshaw

[CS04]

I really do wonder what the 1 star review was for!

Possibly when I misclicked the wrong location at the airport and the driver spent like 20 minutes trying to find me