Log type function. Most of the benefit comes at the higher % immune.
1 Like
My pony broke its leg running over a log.
2 Likes
I looked into this some more and this makes sense. Goes to show the limitations of intuition
3 Likes
if this works covid will be a net positive on humanity.
5 Likes
Was no one working on this before? People have been talking about mRNA vaccines for a while.
Yeah, I feel like this would have been developed COVID or no COVID. Maybe COVID allows them to develop it a bit faster, so could be some net lives saved. Maybe.
Think theyâve been âworking on itâ for decades, they werenât sure how safe it was and urgency of COVID made them say fuck it, YOLO and roll the thing out. Who knows when they would have put it to use otherwise.
1 Like
I remember thinking something similar would happen when people started to develop anti-viral drugs for AIDS. And maybe it did but I donât know enough to see what led to what over the last 40 years.
I think people were working on it, but the hundreds of billions/trillions of dollars that suddenly got thrown at it in the past year advanced the cause quite a bit.
2.5 millionâall black and brownâpeople die from malaria every year: Insert shrugging unicode guy
2.5 millionâmostly whiteâpeople die from covid: Weâve figured out mRNA vaccines!
2 Likes
This saRNA strategy is meaninfully distinct from the mRNA strategy of the Pfizer and Moderna vaccines. This RNA encodes for two things, the gene of interest as well as Rep, which is apparently a primer-free RNA-templated RNA polymerase, that can amplify the RNA in question and thus produce more RNA and can be effective at lower initial dosages of RNA. That gives me a lot more safety heebie geebies than the mRNA vaccines, which only produce one thing, the antigen.
2 Likes
AstraZeneca got their start working on a (as yet unsuccessful) malaria vaccine.
1 Like
God dammit Iâm just realizing I meant to put this in the covid thread
What are they saying about having maskless indoor sports, including wrestling?
hmmm any idea on why you would do that? My understanding is that rRNA was robust enough that you didnât need an RNA polymerase. Maybe because theyâre doing something specific with malaria?
also, thanks for the merge
Actually, the 1 - 1/R0 term is the mirror image of the (1 - % immune) term youâre questioning. When % immune equals the herd immunity percentage, new infections = past infections * R0 * (1 - (1 - /R0)) = past * R0 * (1/R0) = stable infection rate, and then declining after that as % immune increases. In the basic model, for a given level of active infections, population immunity is a linear reduction in the number of new cases.
1 Like
Iâm not sure. I mean, to a certain extent, the proof is in the pudding: AstraZeneca hasnât been successful with DNA incorporation followed by transcription, but this strategy is working. Perhaps you need just that much more production of a PMIF analog/fragment in order to be effective? I donât have the opportunity to read the primary research on it at this point.
1 Like
Once Kurt Angle gets vaccinated weâre going to have 141 and 2/3% immunity
5 Likes
So Iâm a lil shook. Iâm a week out from my second shot and I have a sore throat and had a headache two days ago. I havenât been around anyone not in a masked environment though. Just getting the vaccine, and the grocery store twice.
Iâm probably being paranoid, but this is the first time Iâve felt remotely sick in a year, and if I caught something itâs likely covid.
Fuck that would suck lmao. Scheduled a test for tomorrow and staying away from moms and being masked in the house.
6 Likes
Given that youâve been social distancing, it seems pretty unlikely that you contracted a case of symptomatic COVID one week after the 2nd shot.
But I guess better safe than sorry.