COVID-19: Chapter 7 - Brags, Beats, and Variants

Are you asking because you sort of remember the concern about NSAIDs such as ibuprofen possibly being bad for COVID patients?

oh god i forgot the uk/ireland has crazy rules about acetaminophen (or I think yā€™all call it paracetamol?)

nsaids work fine too, that early work saying they hurt was debunked. Can upset the stomach a bit more.

I go to the grocery store after 10pm and I suspect thatā€™s what Gregorio was out doing as well.

tylenol is the same thing as paracetamol, just a specific brand. IIRC, and I could be wrong on this, itā€™s the packaging requirements somehow.

tbf you may be right, costco sized tylenol is enough to kill someone in a slow agonizing way.

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You seem to be implying the severity of the new COVID strain is worse for younger people and people not generally ā€œat riskā€. What is making you think the new strain is leading to worse outcomes for a given individual? Somewhat early days, so I wouldnt rule it out especially given some of the speculation around higher viral loads, but the studies done to date donā€™t really indicate that is the case, do they? We know that COVID typically affects those with certain risk factors more, but also that there is a small proportion of seemingly not at risk people that get very sick with COVID for reasons we dont yet understand. Why do we think the new strain is different?

Thatā€™s fine, maybe I misunderstood, just checking if I missed something

A new strain can rise in % of population do to two different reasons

  1. More effective transmission
  2. Founder effect

The founder effect is especially in play in a superspreader scenario in that a single infection can rapidly spin off hundreds of infections.

Given the preponderance of the same variant showing up across large geographies with limited travel, I think we can assume that is much more likely improved transmission than founder effect.

The strain spreads better

Next is gain of function outside of transmission. In this case there does seem to be evidence that the demographics of spread among younger demos is more likely vs the parent.

Lastly is there is a change in morbidity? Does it cause disease in a higher percent in certain populations (especially the younger set and perhaps this with less comorbidities).

Without controlling for higher spread, thatā€™s got to be really tough to determine this early. If there are 30% more case in a certain group weā€™d expect to see 30% more disease/death of the morbidity character remains the same.

I think we need to wait some time before making big judgements.

But again, plain old Covid is bad enough that our actions should be more extreme to reduce spread. But if this is what it takes to get people to take action, so be it.

^above is my opinion based on lay literature and popular press.

Yeah, I mean Iā€™ll often post what I thinkā€™s an interesting article without implying I endorse it - but because some people have taken that to mean I agree with every word in it Iā€™ve started adding caveats.

lol internet

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Thereā€™s also changes in population behaviour that would influence the breakdown of hospital admissions by age.

eg if many more young than old people ā€œgave upā€ on strict lockdowns and began partying and socialisingā€¦

Those without links are mostly, if not exclusively, rolling news pages (BBC, Sky maybe). The problem with linking to those is that their content changes and the piece you intended to link to is further down the page. Sometimes itā€™s better to not link at all as it can be confusing once the content moves. (There are no # bookmarks on the pages either to my knowledge)

Adding a generic link to the page might be worth doing though but that would need to be via ā€œadd hyperlinkā€ rather than a simple link paste so as not to include the current snippet.

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This seems wrong. Their stories should have some sort of permanent link that allows them to be shared via social media. A look at the BBC News website suggests you can click the share button to get a URL.

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So they do ā€¦

Iā€™m having trouble with that though when trying it out - always pastes the first article I copied even when I copy other share links on the page? Iā€™ll keep tryingā€¦

Are you using that sideways V with the three dots?

Yes.

I see whatā€™s happening now - itā€™s giving me the same embed summary for each sub-article but will take me to the correct one on click. They should use different summaries for each section.

Was just using the above as my test but have always loved the description of the Isle of Man I heard years ago ā€¦ 80 thousand drunks hanging to a rock :slight_smile:

edit: The article linked is
Clipboard01

Second stick just now. Planning on tylenol and sleep after the night shift I just did

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https://twitter.com/jdavidgoodman/status/1347211235582947328?s=21

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Youā€™ll always get the same non-specific graphic and a warning that you are posting the same link again.

The copy paste usually contain the original source e.g.

ā€œI have admitted patients to the intensive care unit in their 20s and 30s, people who have no pre-existing conditions,ā€ he tells the PA news agency.

Iā€™ve been in the thread since Feb 2020 - the links should not be controversial to others IMO

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Wife got the first jab yesterday. I made sure I was never more than 15 minutes away from her job until it was over. If they had an extra dose I was for sure going to be there with a giant smile on my face.

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Yes. Iā€™m just looking from the virusā€™ viewpoint. There is a claim itt that it not only spreads fast but has higher morbidity. Iā€™m trying to define the distinction between infectiousness and disease causing.

If you want to quote the claim I might be able to help.

UK Variant - guestimations show more transmissibility, no more deadly (however effect of way more cases is health care can cope way less / less oxygen / less ambulances rides might imply a slightly higher CFR.) Now approaching being the dominant strain throughout the whole UK, new variant announced 18th Dec so maybe we can start the studies soon.

South African Variant - more transmission, South African Health minster claims more deadly, now looking like it is antibody resistant, spreads well in the summer.