Well per some quick googling and looking at who manufactures these, your m357 and m367 pills are made by the same manufacturer.
Whoa, there buddy, youâre shifting back and forth here. Letâs stick to this:
It seems like there are at least two different conversations happening here, and all of them sound stupid.
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Yes, and they still donât hit exactly the same. More hydrocodone and less tylenol makes the 367s hit harder and more fun. But itâs not like people throw away the 357s. They just prefer the 367s. The yellow Norcos were even better. Whatever they did or didnât put in those made them hit harder.
So thatâs why I think maybe the yellows were also a crappier brand. Or yeah they could be counterfeit. But I donât think that was the only time my friends got them. So youâd think at some point theyâd get non-counterfeit.
Iâm trying really hard to get it down to one, and yes, it is still incredibly stupid.
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So, you donât think the professional pharmacologists whose job it is to study this stuff never thought of this and/or never published it anywhere. You donât think any of them ever thought âHey, maybe we should figure how how this âdelivery stuffâ affects drug bioavailabity and effects?â
Again, to be clear, weâre talking same brand. Two 5s vs one 10.
Iâm not sure pharmacologists are spending a lot of time measuring the rush when a drug hits.
I like how you just ignore the whole generic thing and are still sure that all this stuff is considered thoroughly in every other aspect of drug formulation. Like the same pharmacologists and FDA that let generics run wild is somehow policing if a drug hits different when you have double the delivery agent to drug ratio.
Used to be the same fucking argument with the calories in / calories out guys who insisted that there are no other variables at play. Me knowing my own body and lived experience counted for nothing. Turns out tons of shit like BMR and fat absorption is variable based on your bodyâs fat thermostat, and theyâre finding new stuff all the time.
Iâm not ignoring it. I said multiple times that there are reasons why different brands can be different. Or if youâre getting entirely fake pills. Or if company is making fake pills. I have even highlighted it in neat little boxes by quoting it for you. Youâre the one ignoring it.
Letâs stick to real point of contention here. Same brand, two 5s vs one 10.
Well, they can ask. Thatâs why as I said earlier, a randomized, blinded trial would put this to rest and if there was any plausible reason for this to occur, there would be a massive incentive to investigate and publish this finding.
Fucking hell I havenât been on a Melk Alice in Wonderland endless merry-go-round argument in a long time. Donât miss it. Iâm done.
Right, theyâre going to do a trial on people taking a pain pill for recreational purposes. JFC
Fucking hell I havenât been on a Melk Alice in Wonderland endless merry-go-round argument in a long time. Donât miss it. Iâm done.
The Tylenol doesnât affect anything with the opiate. Itâs there just to make sure something else can poison you if youâre taking too much
Whoa there CN, donât go discounting suzzerâs âlived experienceâ with all your fancy medical facts.
No, they would do a study on how it affects either healthy volunteers or people who take it for its intended purpose. As part of the study they would likely ask about other effects such as a feeling of euphoria, which is a known side effect of opioids.
Iâm really grasping at the bounds of the craziness of your thesis, but are you now suggesting that two 5s vs one 10, same brand is the same, EXCEPT for the getting high part.
Suzzer your premise is pretty crazy.
So is the premise that my friends, who were pill maniacs at the time, all deluded themselves into thinking that two yellows werenât as good as one blue. Because of mass delusion or something, even when they already had sunk cost on the yellows and had every motivation to like them.
Like Iâve always said, AI is infallible and should always be trusted.
The AI probably just found your argument on here and used that to generate the answer.
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I am trying to come up with anecdotal examples of similar delusion but donât have any for you now. I just know people can convince themselves of some crazy stuff especially when they want to believe.
My personal experience with 5 and 10 mg hydrocodone are that two 5s are the same as one 10.
I am not saying your theory on Valium is without merit, it just seems unlikely.
Iâm even willing to accept that they can be different if different brands (unlikely that the difference is so dramatic, but possible for reasons that have been covered).
The crazy premise is that heâs insisting that two 5s and one 10 of the same brand/manufacturer are so different. The âdelivery stuffâ theory is cool and all, but you would have to believe that it is true AND there is no published evidence of it. Also I havenât weighed a 5mg and 10mg pill, but Iâm sure that they both weigh way more than 5 or 10mg, which means that the active ingredients are a very small percentage of the total weight. But Iâm sure for suzzer and pals, that tiny difference is everything.
Were you taking the hydrocodone for fun or for pain?
Pain