Well I can guarantee you from my druggie days that two 5mg Valiums is not the same as one 10mg. And all other fun drugs work the same. Whatever they cut it with takes down the effect. Maybe Omeprazole is different.
Same with a grain alcohol drunk is very different from a whiskey drink, which is different from a beer drunk. It hits quicker.
Iâd bet Clovisâ net worth if we did a randomized, double-blinded trial on two 5mg Valiums vs one 10 mg valium we would find no statistically significant difference in anything.
With the alcohol there are plausible reasons why those things might be absorbed differently.
We had a million yellow 5mg Valiums. After a while nobody even wanted them. But the 10mg blues were still very popular. No way this was all in our heads. Believe me, people tried to have fun on the yellows many many times.
Same way with 750mg vicodin vs 375mg. Although the 375s were still fun. But the 750s hit you so much harder. I think itâs a time delay thing.
People often think all sorts of dumb stuff and then you do a good experiment and the truth is revealed. I can find you large communites of people who believed vaccines caused their kids autism. In all likelihood they believe in it with greater conviction than you believe this.
Itâs absolutely plausible that people believe that 5mgs were significantly worse and so that is how they experienced them. Placebo effect and similar are real phenomena.
Not when youâre trying to have fun and want them to work. Youâre trying to apply a thought experiment to real world experience. I thought we learned the perils of that with ACism.
Thereâs also so much ridiculous variability that goes into these drugs depending on the brand as well. The yellow norco vicodin 750s were much better than the regular white 750s.
My pharmacy has given me 4 different brands of Ritalin and theyâre all very different in strength and time to take effect.
We know brands make a huge difference because there was just a huge scandal with generic manufacturers cutting corners. What they put in these things to cut them makes a difference in how fast and hard they hit.
That could also apply to dosages. They want you on the heavier dose so thereâs probably some incentive to make the smaller dose crappier. And this was back in the 90s when it was still the wild west out there.
Ok a two things:
Yeah I can totally buy that Omeprazole isnât like the fun drugs.
People are really fucking bad at determining what medicines are effective. Iâd be shocked if you were able to figure out what pill was what if you were blinded just like how most people canât pick out different types of sodas when blinded.
Nah, man. I am drawing a distinction between anecdotes and actual evidence.
I can believe that there might be some variability in brands. I can also believe that a timed release version is different from one that isnât designed that way (obviously).
When getting approval for these drugs the companies have submit some sort of studies on the biosimilarity of the drug, to show that itâs pretty much the same thing. They donât just get to make up whatever pill they want and start hawking it once the other guyâs patent runs out. Despite that, I can accept that in certain individuals, maybe a certain brand of one med might work better than another. But even that seem unlikely to be universally true to a statistically significant extent, your anecdotes notwithstanding.
Not gonna Melk with you all day with you on this.
Two of these:
Is not the same as one of these:
Period. Maybe it was a brand thing. Maybe itâs different now.
I got the exact same thought experiment pushback when I said my Ritalins were different, and then lo and behold it turned out that generics were actually wildly all over the place in quality and amount.
Iâm not sure what these pictures are supposed to show suzzer.
I donât even know what you think that proves.
Looks man, if you want to believe the anecdotal evidence of a bunch of what Iâm sure are highly reliable recreational drug users over whatever studies were submitted to the FDA to get these drugs approved, then go right ahead. You sound like one of those anti-science dolts that we make fun of daily.
Those are the blues and yellows as I knew them back in the 90s. Everyone wanted the blues and my friends couldnât give away the yellows.
I was never really into valium. But I can tell you that vicodins are not the same either.
These are the more fun ones:
And this is the gold standard (no longer made because the patent ran out or something):
Have you considered the possibility that people are faking the pills suzzer, and the more common dosage is being faked more?
Okay, so how did generic manufacturers get around these stringent FDA regulations for decades?
Ebanâs account of Ranbaxyâs shady practices begins in the early 2000s, but it would take years for the FDA to learn about the malfeasance, and even longer for the regulatory body to take action. Ebanâs reporting tells that story, drawing on interviews with more than 240 people, including FDA inspectors and Dinesh Thakur, a former Ranbaxy chemical engineer and whistleblower.
But at Ranbaxy, Thakur encountered a web of systematic fraud. The company often used lower-quality ingredients to save money, manipulated quality control data, or just made up numbers out of thin air. (These details were cited in the 2013 court case that the Department of Justice ultimately brought against Ranbaxy USA.) As a result, as the case alleged, the company was selling drugs of dubious purity, thus potentially endangering patient safety.
So we know there was massive difference in quality and effectiveness for brands, and this went on for decades. But youâre still quite sure there could never be a thing where two smaller dosages !== one large dosage because thought experiment. Okay.
Maybe the yellows we had were a different brand. I donât think we ever cared about that, just the color and amount.
I think itâs actually more likely that the yellow batch was a crappier brand.
Are you even reading my posts, man.
Sure, if one company is committing fraudulent studies, that could explain it
So, to be clear, do you accept that two 5mg Valiums of the same brand is no different than one 10mg valium. Or are you going to die on that hill also.
No because what they cut it with makes a difference in how itâs delivered, which is the fun part. If you have the same amount of cut, but half of the drug, itâs going to hit different. Itâs not like these pills are pure drug. Thereâs all kinds of other delivery stuff.
You know that its actually really easy to press a pill into a certain shape and number on it right?
And itâs also easy for one brand to be crappier than the other.
