https://twitter.com/GovRonDeSantis/status/1425862297835216899
I’m confused - are anti-vaxxers ok with monoclonal antibodies?
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Sounds like stuff for people who don’t trust their own immune system, iyam.
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All these different studies on the effectiveness of vaccines is super confusing to me. Study the other day says 42% for Pfizer and 88% for Moderna. How does that make any sense? Why would one be so much better then the other? Now this study makes me feel better cause I got Pfizer, so I’m all woohoo!!. It’s super frustrating not knowing what study to believe and what is just clickbait.
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The study you’re referring to isn’t peer-reviewed, but assuming it’s legit, the way to reconcile the two results is to conclude that the efficacy of Pfizer drops precipitously over time. Maybe some wrinkle in the specific antigen they’re each using makes the immune response more durable for Moderna.
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Big thanks to everyone in this thread, especially the medical workers whove shared stories. Had been considering waiting on my 2nd vax dose since I had to cross TJ/SD border, but was rightfully scared straight from recent event and reading here.
Things in Mexico seem to be popping off. Hopefully a big part of the 20pct fully vaxxed are elderly and vulnerable so fatalities stay low, but they seem to be going sharply up too.
Have an unvaxxed local friend who is 30, morbidly obese and history of asthma. He says he can’t take the time off to get it and possible side effects… but I think a lot of it is anxiety of the border and entering US for first time in like 5 years. I’ve been upping pressure on him to just do it, offering to cross with him and everything. I’ve giving up trying to give him life advice In other areas cause it’s a waste of time. But the chances this kills him in the next few years are way higher than he thinks.
Might just have to “hope” someone unvaxxed close to him gets really sick and it scares him straight
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As one of the tweets suzzer posted says, that study had wide confidence intervals. The effectiveness reported in July for moderna was 76% with a 95% confidence interval of 58-87%. Pfizer had 42% with a CI of 13-62%. The intervals overlap, so this is not strong evidence that moderna is better than pfizer.
Also, this study may understate the effectiveness of both vaccines. Some people in the unvaccinated group probably had some immunity due to prior undetected covid infection, because many asymptomatic/mild infections go undetected.
That depends - does it trigger the libs or not?
Exactly this. Think of confidence intervals as error bars.
There are lots of ways to do these studies.
The lay evidence in terms of disease and death reduction is overwhelming. There are not any significant number hospitalized or dead vaccinated folks.
That’s what you need to know.
The CDC has made some missteps but on the whole you can’t go too wrong following their advice. We may be a little ahead of the info curve here—ie it’s obvious that we will be getting some kind of booster before years end. Just another shot if a Delta specific booster is not ready.
Moderna injects more RNA is one theory (not willing to confirm that M>>Pfi from the totality of what’s out there).
I played tennis with a Pfizer guy. The sequences are essentially identical according to him.
The use of the “precipitous” is not warranted based on the overall info available.
But none of this changes the advice
Mask back up
Stay out of indoor crowds
Encourage others to get vaxxed
Do not send unvaxxed kids to school without mandatory masking.
We really need to start oppressing the unvaccinated. Really oppressing not fake oppressing. This parent should be facing 5-10 years.
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Eh, depends on how much overlap there is.
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I see BACK TO SCHOOL is starting off swimmingly.
There was a period back in the 80’s when AIDS patients would be criminally charged for knowingly passing or attempting to pass the virus. Not sure how this is different. Can’t recall though if those AIDS cases were thrown out of court.
Those AIDS laws are still enforced today.
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And how wide the range. 15-61 is yuge.
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I wonder how many anti-vax people use Botox
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I don’t think this is quite right. Nonoverlapping confidence intervals are sufficient but not necessary to show a statistically significant difference. E.g., imagine that the true efficacy of both Moderna and Pfizer is 60%. You’d observe an efficacy rate of at least 76% for Moderna more than 5% of the time by random chance alone, and you’d observe an efficacy rate of no more than 42% for Pfizer more than 5% of the time by random chance alone, but those outliers are independent events. You’d need to have Moderna come in with a high outlier and Pfizer come in with a low outlier (or vice versa) to see a difference this large. If the likelihood of those outliers is, e.g., 10%, then the difference is significant.
The Mayo Clinic study gives the CI for the relative infection risk for Moderna vs Pfizer as (0.21, 0.76) in Table 3. (EDIT: This is for July only–no significant difference in prior months)
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