COVID-19: Chapter 10 - Mission Achomlished!

Id feel better if I knew there wasnt a way for Delta to mutate into a more contagious/severe/evading Pi in a similar way Alpha mutated into Omicron as Im not sure Omicron is actually less severe than Alpha or OG Wuhan on an apples-to-apples basis (vaccines, treatment, and vulnerable already being exposed/killed makes this a harder worldwide population to attack than in March 2020).

From my very basic understanding seems like it would be hard for Delta to evolve in the exact same way to increase transmission, but I can certainly find immunology PhDā€™s who have theories of particular evolutionary changes to Delta that would be quite bad in terms of increased severity or immune evasion.

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What did I say about citations?

I donā€™t remember - what did you say about citations?

Itā€™s pretty obvious itā€™s from The Guardian if you hover over the only link lol.

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Edit: Iā€™m just getting word that the Court has corrected its official transcript to show that Gorsuch did wear a mask

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The U.S. seven-day average reached 140,576 people hospitalized with confirmed and suspected Covid-19 cases on Tuesday, more than the previous high recorded during the surge last winter, according to a Wall Street Journal analysis of U.S. Department of Health and Human Services data.

Hospitalization numbers from early in the pandemic arenā€™t comprehensive enough to show levels from the earliest waves.

I donā€™t have the book handy but Spillover has an interesting part about myxomatosis in Australia and how it evolved into 5(?) different strains and the dominant one was one of the more deadly and the mildest one was rapidly outcompeted. There are more factors in play than just how deadly a particular strain is, there was an example of a human disease (smallpox or measles, I think) that is super deadly but relies on having a large population of uninfected people to keep itself going.

That was my bet (positive as a lie). What do I win?

If he lied that will banhammer for 3 years and tennis should do the same worldwide for 1.

I generally think amplifying dunks on idiots is bad, but this is pretty good stuff. Lolā€™d at Randā€™s stupid face, god bless that neighbor.

https://twitter.com/gunsdownamerica/status/1480944235645964304?s=21

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Why do Chuck and Nancy give Rand a hot microphone? Cant they yank his chair and give it to someone less Qanon-adjacent?

Interesting. This was a good point toward the end

ā€œAerosols will fill up indoor spaces rapidly in the absence of proper ventilation, so assuming the infected individual remains within the room, the levels of virus will be replenished.ā€

So I read this asā€”if the same infected people keep spewing out live virus in the same space then practically the 5 minute thing is really just going to impact the steady state and the environment will still be infective until that person leaves or some other factor (ventilation) pulls out the particles/droplets or hastens drying.

Clearly we know from some of the earliest studies that steady air currents from spot A to spot B can act as streams to carry the infection at least 10s of feet.

Also remember that Covid is already a ā€œless deadlyā€ disease. The endgame of death happens after an individual has already had lots of time to spew virus.

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Better late than never.

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More Fauci excellence. Make sure to listen to the end.

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Man Iā€™m used to complete imbeciles in the House but I was under the obviously misguided assumption that Senators are better. That guy is dumber than a box of rocks.

Whatā€™s up everyone? Iā€™m back! Of course I have some thoughts on the current situation in the pandemic and the current situation ITT, that can hopefully get people to talk past each other a bit less and be a bit less accusatory.

One thing that I think a lot of people might be missing in this back and forth is that everyoneā€™s precaution level can (and SHOULD) be changing over time, and that doesnā€™t automatically mean you got it wrong before.

There are a lot of attempts to go for a ā€œgotchaā€ on other posters based on what they said months ago. Pre-Omicron was a different world, just like pre-Delta was a different world, just like pre-Vaccine was a different world.

It can be correct to have been pretty damn close to normal 3-6 months ago once boosted (as protection vs Delta was very good), but it is clearly not a good idea to be close to normal right now if you want to avoid Omicron.

I was playing unmasked poker for a while post-booster and pre-Omicron. I felt safe doing so. Now Iā€™m basically treating things the way I would if you dropped me into March 2020 in a time machine with my current knowledge: N95 for trips to the store, only seeing other people who I know have been careful the last 10-14 days before seeing them, nothing in person and unmasked where thereā€™s potential exposure. Iā€™m masking outdoors on the way into stores, mainly because the level of extra inconvenience is inconsequential and it canā€™t hurt, and there may be outdoor spread of Omicron.

That doesnā€™t mean I was wrong a couple months ago. I think thereā€™s a significant likelihood that this continues for years, maybe even the rest of our lives (hope not), and the key to maintaining happiness and sanity while minimizing risk is to adjust your behavior/precautions to the data and your current booster status.

One thing we know for sure is that barring a HIGHLY lethal new variant, western society is done trying to prevent the spread of COVID-19. These are individual decisions. Perhaps in some communities, cities, regions, etc there are more precautions being taken - thatā€™s great. In others there will be ~none. We have to decide how to live in the areas we live in and make personal risk decisions. We can criticize society at large for how this is being handled, but that doesnā€™t change the fact that we have to live within the society we choose to live in and make the personal decisions that society is leaving to the individual.

My primary concern from here on out is avoiding Long Covid, especially after Fauciā€™s latest comments and the data out of Finland. Thus Iā€™m trying to personally mitigate my risk of catching COVID-19 to as close to zero as possible, unless/until we see data that vaccines, Paxlovid, or other treatments prevent most of the risk of Long Covid - especially the cognitive side of it, or anything that would take significant years off of life expectancy. Iā€™ve seen conflicting data, expert opinions, etc on whether severity of case is linked to likelihood of and/or severity of Long Covid. So I feel like we simply donā€™t know yet.

The other thing about Omicron is that itā€™s so widely prevalent right now that even a highly efficacious vaccine is going to be tested FREQUENTLY. So to pull some numbers out of my ass, if the average unvaccinated person would have a 25% chance of infection in a certain situation, and the vaccine gives you 75% protection over that, you have a 6.25% chance of infection. Thatā€™s significant protection! But if you roll the dice on that type of situation five times a day for a month, guess what? Youā€™re probably going to catch it, at which point you can rely on the extremely good protection against severe cases.

Iā€™m very curious what others, especially some of our resident medical/science experts, think about the situation right now with Long Covid. How concerned would you be about it, being double vaxxed and boosted? Do you think itā€™s going to end up being strongly correlated to severity of case? In particular the cognitive side of itā€¦

Last but not least, I find it absurd that we arenā€™t doing a massive study somewhere in the world on how the common cold coronaviruses spread. Are we all being infected every year, but the vast majority are asymptomatic? Are they surging in two waves per year and not one? Do they cause any long-term effects?

It seems like a study aiming to track the spread of regular coronaviruses would offer a lot of insight into the eventual end-game of COVID-19. If the regular common colds are spreading asymptomatically and like 90% of us catch them without even realizing it, their R0 is much higher than we previously thought, and we can probably conclude that asymptomatic infections donā€™t do much of anything to us and proceed accordingly.

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This was quite the pleasant surprise while I was scrolling through selecting posts to split off into a new thread. I hope I donā€™t read the post and you end it by saying youā€™re leaving again.

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Welcome back @anon38180840!

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Would be highly interested in reputable long COVID studies that show treatments are effective as the stuff Iā€™ve found leaves me very uneasy. One of my fears is this is an endemic disease where the acute stage is becoming more treatable but that is still going to lower our life expectancy meaningfully when we repeatedly catch it and leave us vulnerable in particular to things like Parkinsonā€™s and auto immune disorders.

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I feel like the answer to your last question there has to be no, because we would know about itā€¦ hopefully. But yeah the first two questions are interesting.

Redacted for privacy.

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