COVID-19: Chapter 10 - Mission Achomlished!

With 2yrs history on the pandemic, simple maths should tell us whether an old with and who visited grandkids would be more likely to die than an old without grandkids. Alternatively, did more parents with kids catch it than peeps without kids? Did an unproportional amount of teachers cark it? Countries that contract traced / genone sequenced know the answers to this.

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Keep fucking that chicken.

Oh can you share that data?

Update: still sick but recovering, felt relatively better after a few days. thank god. lots of gunk/headache/mild fever, never had any oxygen issues.

She went to buy the oximeter for delivery when you suggested it, so thanks!

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Number 1 Spartan son pozzed this weekend. His office took a team building trip to New Orleans.

Mild so far.

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how serious is covid recurrence?

Sure seems like COVID is well on its way to being endemic.

https://www.nature.com/articles/d41586-022-01240-x

Looks like it’s turning out to be the flu in the Czech Republic with a surge of cases in the fall/winter, a substantial decline starting in the spring and bottoming out in the summer.

Right now, only five countries in the EU have a lower new covid cases per capita over the last 7 days (Lithuania, Sweden, Bulgaria, Romania, Poland).

The percentage of people hospitalized with covid in intensive care is at the lowest its been since the very beginning of the pandemic over 2 years ago.

Seems like the most important part for people who can’t be bothered to click:

A team led by virologist Alex Sigal at the Africa Health Research Institute in Durban, South Africa, analysed blood samples from 39 people who had been infected during the first Omicron wave, 15 of whom had been vaccinated2.

In lab experiments, antibodies in these samples were several times less effective at preventing cells from being infected by BA.4 or BA.5 than they were at keeping out the original Omicron strain. However, antibodies produced by people who had been vaccinated were more potent against the new variants than were those from people whose immunity stemmed solely from BA.1 infection. The study was posted on medRxiv.

Another study3, posted on the ResearchSquare preprint server and led by virologist Xiaoliang Xie at Peking University in Beijing, also found that antibodies triggered by BA.1 infection were less potent against BA.4 and BA.5. Moore says the results chime with her unpublished experiments, too.

BA.4 and BA.5’s capacity to escape immunity, although not dramatic, “is enough to cause trouble and lead to an infection wave” — but the variants are not likely to cause disease much more severe than was seen during the previous wave, especially in vaccinated people, Sigal said in a Twitter post. “They clearly have an advantage in antibody escape, which is one contributing factor in why they are spreading,” says Bloom.

This lines up with what we’re seeing in my area. Our reported new daily cases is comparable to the 2020 holiday wave, and we know that’s an underestimate. But hospitalizations, like, it’s not clear there’s even an upward trend at this point, and that’s after the uptick has been going since late March, 8ish weeks ago.

In Vermont, hospitalizations have been soaring since late March:

Kind of looks like we might get waves of BA and Delta every year as peoples immune systems adapt much like we have different flu strains.

Gonna be wild with such a mix of variants, infection acquired antibodies and various vaccines and regimes.

Fingers crossed, Moderna will be approved for kids <11 within about a month.

https://www.nejm.org/doi/full/10.1056/NEJMoa2203315

CONCLUSIONS
Two 50-μg doses of the mRNA-1273 vaccine were found to be safe and effective in inducing immune responses and preventing Covid-19 in children 6 to 11 years of age; these responses were noninferior to those in young adults.

One the one hand, great. On the other, what about 5 and under, motherfuckers?!

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dammit saw under 11, but it was 5-11. Come on under 6mo-5yr

https://twitter.com/PostWorld/status/1524555820851159040?t=Up3T-j3q0p2QmONwNGpoXw&s=19

Sounds like they’re looking for approval for everyone?

The company is seeking approval for the use of its vaccines in three distinct age groups - adolescents aged 12 to 17 years, children aged six to 11 and those between six years and six months. The submissions for all three groups were made on May 9, it said.

I’ll calm down when I see the actual data.